ESHRE热点累积玻璃化冷冻卵子改善

P-CumulativeoocytevitrificationimprovesPreimplantationalGeneticScreening(PGS)clinicalresultsinlow-responderpatients

P.BuendiaSegura1,A.Cobo2,C.Rubio3,A.Mercader1,A.Delgado1,L.Escrich1,D.Beltran1,E.Bosch4,J.Remohi5.1IVIValencia,PGD-IVFlab,Valencia,Spain,2IVIValencia,Cryopreservation,Valencia,Spain,3Igenomix,PGD,Valencia,Spain,4IVIValencia,ClinicalDirector,Valencia,Spain,5IVIValencia,Director,Valencia,Spain

Studyquestion:PGSresultcouldbeinfluencedbythelownumberofoocytesobtainedinlow-responderpatients.

Summaryanswer:Accumulationofvitrifiedoocytesequatestheclinicalresultsinlow-responderPGSpatientswhenthenumberofcollectedoocytesapproachestheoneinnormo-responderPGSpatients.

Whatisknownalready:OocytevitrificationdoesnotincreasetheincidenceofchromosomalabnormalitieswhenweanalyzedinaPGScycleembryosfromfreshandvitrifiedoocytesfromthesamepatient.

Studydesign,size,duration:ThisretrospectiveobservationalstudyincludedPGScyclesfromnormo-responderpatientsinwhichtheoriginoftheoocytesofallembryosanalyzedwerefreshand45PGScyclesfromlow-responderspatientswheretheoriginofallanalyzedembryosderivedfromvitrifiedoocytesfromtwoormorecyclesofovarianstimulationfromourPGDprogram(fromJanuarytoDecember).

Participants/materials,setting,methods:patientswereincludedinthisstudy,withfreshoocytesand43withvitrifiedoocytes.OocyteswerevitrifiedbyCryotop?method.Biopsieswereperformedonday3inCa2+andMg2+freemedium(G-PGD,Vitrolife)usinglasertechnology(OCTAX).For24-chromosomeaneuploidyscreening,array-CGHwasemployed.Euploidembryosweretransferredonday5,supernumeraryembryoswerevitrifiedeitheronday5orday6.Statistical







































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